The council chambers will be open to the public for the meeting. Masks are highly encouraged where 6-foot distancing cannot be maintained.
If you cannot attend in person, and would like to speak on an agenda item, you can access the Zoom meeting remotely at this link or join by phone by calling toll-free 669-900-9128 or 346-248-7799.
The webinar ID is 973 6820 1787, access code is 477973; the audio pin will be shown after joining the webinar. Those phoning in without using the web link will be in “listen mode” only and will not be able to participate or comment.
Comments can be submitted by email to This email address is being protected from spambots. You need JavaScript enabled to view it.. To give the city clerk adequate time to print out comments for consideration at the meeting, please submit written comments before 3:30 p.m. on Tuesday, March 19.
On Tuesday, the council will start off the evening with the introduction of new employees Bryan Carlson, Mel Olea, Jen Baker and Michelle Brown.
The council will hold a public hearing ahead of its consideration of adopting a 2% permit fee for permit processing, inspections, public awareness and education campaigns, and fire operations and suppression efforts related to the sale of safe and sane fireworks.
City documents indicate the city already has a 5% permit fee on the fireworks.
The city of Lakeport is the only place in Lake County where fireworks are permitted. That’s because voters passed Measure C in November 2009 after the council had attempted to end fireworks sales.
In council business, staff will ask council members to adopt a proposed resolution authorizing the submittal of an application to the California State Department of Housing and Community Development for funding under the HOME Investment Partnership Program.
City Manager Kevin Ingram also will present a progress update on staff’s work to meet the 2023-24 departmental goals.
On the consent agenda — items considered noncontroversial and usually accepted as a slate on one vote — are ordinances; minutes of the City Council’s regular meetings on March 5; receipt and filing of the 2023 Housing Element Annual Progress Report; and receipt and filing of the 2023 2nd Quarter Community Development Report.
Email Elizabeth Larson at This email address is being protected from spambots. You need JavaScript enabled to view it.. Follow her on Twitter, @ERLarson, or Lake County News, @LakeCoNews.
In an effort to immediately tackle California’s budget challenge early in the year, Senate Leader Mike McGuire (D-North Coast) and Senate Budget & Fiscal Review Committee Chair Scott Wiener (D-San Francisco) have announced a plan by Senate Democrats to shrink the shortfall through decisive early action on the budget.
Recent reports indicate the projected budget shortfall has grown by an additional $15 billion, resulting in a potential shortfall range from $38 billion to $53 billion.
The Senate’s early action plan would reduce the shortfall by over $17 billion.
This immediate action takes the shortfall range down to a more manageable $9 billion to $24 billion and enables final budget negotiations later in the year to focus on closing the remaining gap while working to protect the progress of core programs that California has made in recent years.
With a balanced mix of $17 billion of program reductions and other solutions, along with adopting the governor’s proposed use of the Rainy Day Fund, the Senate’s “Shrink the Shortfall” early action plan is step one of this year’s budget process, which will ultimately lead to a balanced, on-time budget for 2024-25.
The Shrink the Shortfall early action plan will be heard in the Senate Budget and Fiscal Review Committee and could come up for a vote on the Senate Floor as soon as there is agreement with the Assembly and governor.
“When times are tight at home, people buckle down and do what needs to be done. That’s what the Golden State has to do right now too. The quicker we move, the quicker we’ll be able to reduce the deficit, and we know we have to move decisively because the budget shortfall is real and serious,” said McGuire.
He said the Senate’s plan to shrink the shortfall protects core programs, includes no new tax increases for Californians, makes necessary reductions, and takes a prudent approach to utilizing the Rainy Day Fund so the state can be prepared for any future tough times. “We look forward to buckling down with Governor Newsom, Speaker Rivas, and our Assembly partners on these responsible early actions, and on an overall state budget that protects our progress for all Californians.”
“After years of strong progress to advance California values, we face a huge budget challenge. I’m honored to be working hand in glove with Pro Tem McGuire and our Senate colleagues to advance smart solutions that address the deficit while protecting our progress. Time is truly of the essence,” said Wiener.
He added, “The early actions we’re proposing, including $17 billion in General Fund solutions, not only reduce the size of the deficit in this budget year and the next, but also give us more time to develop thoughtful solutions to address the shortfall that will remain. Let’s be clear: Shrinking the shortfall early in the process is step one. The Senate’s 2024-25 budget plan will be released later in the spring and will provide a comprehensive proposal for a balanced, responsible budget that protects core programs and services and positions the Governor and the Legislature to best protect California’s progress.”
Mike McGuire is president pro tempore of the California Senate. He represents the North Coast of California, which stretches from the Golden Gate Bridge to the Oregon border, including Del Norte, Trinity, Humboldt, Lake, Mendocino, Sonoma and Marin counties.
MENDOCINO NATIONAL FOREST, Calif. — Mendocino National Forest staff are reopening off-highway vehicle, or OHV, trails and a campground after a closure lifts on Saturday, March 16, at midnight.
Upper Lake Ranger District OHV trails and the Deer Valley Campground had been closed due to extensive storm damage since mid-February.
Forest leadership mobilized volunteers and staff from recreation, fire, fuels and engineering to help with trail cleanup during the monthlong closure.
One campsite in the Deer Valley Campground will remain closed. A picnic table was destroyed by a fallen tree, and staff plan to restore the site when the ground is drier. Forest staff also continue to clear trails and conduct tread repair.
Forest officials caution visitors to be aware of their environment. Trees may continue to fall, and trail riders can expect to encounter downed trees on trails.
Roads in the forest can become impassable at any time due to downed trees, rockfall or slides. In higher elevations, roads remain impassable due to snow and ice.
A new study published in The Lancet reveals never-before-seen details about staggeringly high mortality from the COVID-19 pandemic within and across countries.
Places such as Mexico City, Peru and Bolivia had some of the largest drops in life expectancy from 2019 to 2021.
The research, which presents updated estimates from the Global Burden of Disease Study 2021, provides the most comprehensive look at the pandemic’s toll on human health to date, indicating that global life expectancy dropped by 1.6 years from 2019 to 2021, a sharp reversal from past increases.
Among other key findings from the Global Burden of Disease, or GBD, child mortality continued to drop amid the COVID-19 pandemic, with half a million fewer deaths among children under 5 in 2021 compared to 2019. Mortality rates among children under 5 decreased by 7% from 2019 to 2021.
“For adults worldwide, the COVID-19 pandemic has had a more profound impact than any event seen in half a century, including conflicts and natural disasters,” says co-first author Dr. Austin E. Schumacher, acting assistant professor of Health Metrics Sciences at the Institute for Health Metrics and Evaluation, or IHME, at the University of Washington. “Life expectancy declined in 84% of countries and territories during this pandemic, demonstrating the devastating potential impacts of novel pathogens.”
Researchers from IHME identified high mortality during the COVID-19 pandemic in places that were previously less recognized and/or reported.
For example, the study reveals that after accounting for the age of the population, countries such as Jordan and Nicaragua had high excess mortality due to the COVID-19 pandemic that was not apparent in previous all-age excess mortality estimates.
In analyzing subnational locations not previously investigated, the South African provinces of KwaZulu-Natal and Limpopo had among the highest age-adjusted excess mortality rates and largest life expectancy declines during the pandemic in the world.
Conversely, the places with some of the lowest age-adjusted excess mortality from the pandemic during this period included Barbados, New Zealand, and Antigua and Barbuda.
During the COVID-19 pandemic, mortality among older people worldwide rose in ways unseen in the previous 70 years. While the pandemic was devastating, killing approximately 16 million people around the globe in 2020 and 2021 combined, it did not completely erase historic progress — life expectancy at birth rose by nearly 23 years between 1950 and 2021.
GBD 2021 analyzes past and current demographic trends at global, regional, national, and subnational levels.
The study provides globally comparable measures of excess mortality and is one of the first studies to fully evaluate demographic trends in the context of the first two years of the COVID-19 pandemic.
In estimating excess deaths due to the pandemic, the authors accounted for deaths from the virus that causes COVID-19, SARS-CoV-2, as well as deaths associated with indirect effects of the pandemic, such as delays in seeking health care.
Employing innovative methods to measure mortality, excess mortality from the COVID-19 pandemic, life expectancy, and population, the study authors estimate that the pandemic caused global mortality to jump among people over age 15, rising by 22% for males and 17% for females from 2019 to 2021.
GBD 2021 goes beyond assessing the impact of the first two years of the COVID-19 pandemic. As the authors note, it also offers “implications for the future of health-care systems, economies, and societies and ... a valuable foundation for policy evaluation, development, and implementation around the world.”
GBD 2021 indicates that, despite early warnings that COVID-19 could threaten the gains that the world had made in saving children’s lives, these improvements continued during the pandemic, albeit at a slower pace.
Still, stark differences in child mortality persist between regions. In 2021, one out of every four children who died worldwide lived in South Asia, while two out of every four children who died lived in sub-Saharan Africa.
“Our study suggests that, even after taking stock of the terrible loss of lives the world experienced due to the pandemic, we have made incredible progress over 72 years since 1950, with child mortality continuing to drop globally,” said co-first author Dr. Hmwe Hmwe Kyu, Associate Professor of Health Metrics Sciences at IHME at the University of Washington. “Now, continuing to build on our successes, while preparing for the next pandemic and addressing the vast disparities in health across countries, should be our greatest focuses.”
The GBD 2021 study also assessed population trends. Beginning in 2017, the rate of global population growth began to drop following years of stagnation. Then, during the COVID-19 pandemic, these declines accelerated.
As of 2021, 56 countries have reached peak population. Now, these countries are seeing their populations shrink. However, rapid population growth has continued in many lower-income countries. In addition, populations around the world are aging.
Between 2000 and 2021, the number of people who were 65 and older grew faster than the number of people under age 15 in 188 countries and territories.
“Slowing population growth and aging populations, along with the concentration of future population growth shifting to poorer locations with worse health outcomes, will bring about unprecedented social, economic, and political challenges, such as labor shortages in areas where younger populations are shrinking and resource scarcity in places where population size continues to expand rapidly,” says Dr. Schumacher. “This is worth restating, as these issues will require significant policy forethought to address in the affected regions. As one example, nations around the world will need to cooperate on voluntary emigration, for which one source of useful guidance is the UN’s Global Compact for Safe, Orderly and Regular Migration.”
The COVID-19 virus can persist in the blood and tissue of patients for more than a year after the acute phase of the illness has ended, according to new research from UC San Francisco that offers potential clues to why some people develop long COVID.
The scientists found pieces of SARS-CoV-2, referred to as COVID antigens, lingering in the blood up to 14 months after infection and for more than two years in tissue samples from people who had COVID.
“These two studies provide some of the strongest evidence so far that COVID antigens can persist in some people, even though we think they have normal immune responses,” said Michael Peluso, MD, an infectious disease researcher in the UCSF School of Medicine, who led both studies.
The findings were presented at the Conference on Retroviruses and Opportunistic Infections (CROI), which was held March 3 to 6, 2024, in Denver.
Evidence of long-term infection
Early in the pandemic, COVID-19 was thought to be a transient illness. But a growing number of patients, even those who had previously been healthy, continued having symptoms, such as, brain fog, digestive problems and vascular issues, for months or even years.
The researchers looked at blood samples from 171 people who had been infected with COVID. Using an ultra-sensitive test for the COVID “spike” protein, which helps the virus break into human cells, the scientists found the virus was still present up to 14 months later in some people.
Among those who were hospitalized for COVID, the likelihood of detecting the COVID antigens was about twice as high as it was for those who were not. It was also higher for those who reported being sicker but were not hospitalized.
“As a clinician, these associations convince me that we are on to something, because it makes sense that someone who had been sicker with COVID would have more antigen that can stick around,” Peluso said.
Virus persists up to two years in tissue
Since the virus is believed to persist in the tissue reservoirs, the scientists turned to UCSF’s Long COVID Tissue Bank, which contains samples donated by patients with and without long COVID.
They detected portions of viral RNA for up to two years after infection, although there was no evidence that the person had become reinfected. They found it in the connective tissue where immune cells are located, suggesting that the viral fragments were causing the immune system to attack. In some of the samples, the researchers found that the virus could be active.
Peluso said more research is needed to determine whether the persistence of these fragments drives long COVID and such associated risks as heart attack and stroke.
But, based on these findings, Peluso’s team at UCSF is involved in multiple clinical trials that are testing whether monoclonal antibodies or antiviral drugs can remove the virus and improve the health of people with long COVID.
“There is a lot more work to be done, but I feel like we are making progress in really understanding the long-term consequences of this infection,” Peluso said.
Authors: Additional UCSF co-authors include Sarah Goldberg, MAS, Brian H. LaFranchi, Scott Lu, MD, Thomas Dalhuisen, MS, Badri Viswanathan, Ma Somsouk, MD, MAS, J.D. Kelly, MD, Steven G. Deeks, MD, Zoltan Laszik, MD, PhD, Jeffrey Martin, MD, MPH, and Timothy J. Henrich, MD.
Funding: The studies were supported by funding from the PolyBio Research Foundation to support UCSF’s Long-Term Impact of Infection with Novel Coronavirus (LIINC) Clinical Core and a Merck Investigator Studies Program Grant. The National Institute of Health’s National Institute of Allergy and Infectious Diseases also provided funding (3R01AI1411003-03S1, R01AI158013 and K23AI134327, K23AI157875 and K24AI145806). Additional support came from the Zuckerberg San Francisco General Hospital Department of Medicine and Division of HIV, Infectious Diseases and Global Medicine.
BERKELEY, Calif. — The Museum of Vertebrate Zoology, or MVZ, at the University of California, Berkeley, contains more than 300,000 vertebrate specimens — the majority of them reptiles and amphibians — preserved in alcohol and tucked away for current and future generations of scientists who want to study their anatomical and genetic diversity.
Now, those specimens are gradually gaining a new life online as part of an effort by 25 museums across the U.S. to obtain 3D scans of as many vertebrate groups as possible and make them available free to the general public in a searchable database.
A summary of the six-year project, called openVertebrate (oVert), was published this week in the journal BioScience, offering a glimpse of how the data might be used to ask new scientific questions and spur the development of innovative technology.
But scientists aren't the only ones who find the scans useful. Artists have used the 3D models to create realistic animal replicas, photographs of oVert specimens have been displayed as museum exhibits, and specimens have been incorporated into virtual reality headsets that give users the chance to interact with and manipulate them.
Carol Spencer, staff curator of herpetology in the MVZ, has a 3D-printed version of one specimen — the skull of a horned lizard — sitting on her desk. Anyone can access the 3D scans online at MorphoSource, download the data and send them to a 3D printer to produce their own skeletal models.
"You can actually print them and then use them in a classroom. We have lots of people using them for teaching in colleges or high schools," Spencer said.
Of the approximately 1,000 MVZ specimens scanned over the past six years through oVert, one — a juvenile Australian platypus, Ornithorhynchus anatinus — is the second most downloaded in the database.
"We've had this platypus in ethanol in a big tank, but it's never been loaned out. The only people who have ever gone to look at this are people that come here to our collection; it's maybe been looked at twice in its entire history here at MVZ. But in six years, it's been downloaded 320 times," Spencer said. "That's a huge expansion of use."
Spencer recently fielded a request from a professor at Towson University in Maryland to download CT scans for a course in which students compare the cranial anatomy of vertebrates and print 3D models for study.
"All of these specimens are gaining sort of a new digital life," said Michelle Koo, the MVZ's staff curator of biodiversity informatics. "Specimens are collected all the time, and museums have to justify taking an animal out of the wild and make sure that it has the highest value possible to current and future research. It's part of our responsibility as curators to seek out and help keep developing these new uses and ways of accessing specimens to make sure that they stay relevant and useful for these new cutting-edge tools."
A new digital life
Between 2017 and 2023, oVert project members led by David Blackburn at the Florida Museum of Natural History captured CT scans of more than 13,000 specimens with representative species across the vertebrate tree of life. These scans included more than half the genera of all amphibians, reptiles, fishes and mammals.
CT scanners use high-energy X-rays to peer past an organism’s exterior and view the dense bone structure beneath. While skeletons make up the majority of oVert reconstructions, a small number of specimens were also stained with a temporary contrast-enhancing solution that allowed researchers to visualize soft tissues, such as skin, muscle and other organs.
The models give an intimate look at internal portions of a specimen that could previously only be observed through destructive dissection and tissue sampling, Blackburn noted.
“Museums are constantly engaged in a balancing act,” he said. “You want to protect specimens, but you also want to have people use them. oVert is a way of reducing the wear and tear on samples while also increasing access, and it’s the next logical step in the mission of museum collections.”
Because CT scans yield a series of slices through the specimen, most of the images on MorphoSource are cross-sections that must be assembled into a 3D rendering that can be spun and manipulated in a 3D viewer. But software that does this is readily available, Koo said.
The CT scans resemble what she laboriously assembled as a graduate student at UC Berkeley in the 1990s, when she was studying the unique skulls of a small group of salamanders. Then, she sliced the bodies into thin sections to study the internal anatomy, but hadn't the ability to assemble them into a 3D picture that people could readily appreciate.
"Today, I might still have to do histology, but now that we have a digital rendering of it, I can send them a picture," Koo said. "It's the same thing that I saw when I was looking under the microscope and trying to explain to people."
Though funding for oVert from the National Science Foundation has ended, many museums are continuing to scan their collections, often focusing on specific groups. Spencer noted that MVZ has over 800,000 total vertebrate specimens, pickled in alcohol or dry, that could potentially be scanned and made available online.
Initially, UC Berkeley didn't have one of the micro-CT scanners used by the oVert group, so the MVZ sent specimens to other institutions for scanning. Integrative biology professor Jack Tseng has since acquired one for projects, such as a study of fish and mammal skulls, within his department.
Spencer regularly sends MVZ specimens to other institutions where ongoing studies require a scan. She and Koo are continuing the scanning work started by oVert in a collaboration with the University of Colorado in Boulder, for example, which is leading a project to CT scan and high-resolution 2D image 1,100 species of Central American reptiles and amphibians. About 80 turtles from the MVZ are being scanned by the University of Michigan Museum of Zoology, while some of the museum's legless lizards and cave salamanders are being scanned at other institutions for a study of their evolution. MVZ director Michael Nachman is CT scanning mice to study the connection between tail length and adaptation to heat, and the role maternal genes play in this adaptation.
"oVert's goal was to try to get one of every genus of vertebrate. But then you don't have all this variability within species," Spencer said. "And so really what we need is huge data sets of multiple animals per species. And the only way we're going to get that is if we convince everyone to make their data public through sites like MorphoSource. So when I mail specimens out to someone, and then they do CT scans, I require them to put those CT scans, when they're done with their research, on MorphoSource so that other people can use them."
oVert was funded with an initial sum of $2.5 million from the National Science Foundation, along with eight additional partnering grants totaling $1.1 million that were used to expand the project’s scope.
Robert Sanders writes for the UC Berkeley News Center.
Kendall Houghton, Ariel J. Binder, Amanda Eng and Andrew Foote
The gender wage gap — the difference between what men and women earn — is an often-cited marker of the progress women are making in the work force typically measured by comparing the average earnings of men and women.
Previous U.S. Census Bureau research has explored the gender wage gap and how it varies with social, economic and demographic characteristics.
Now, new U.S. Census Bureau research takes it a step further by comparing male and female earnings for graduates of similar educational programs. Rather than comparing male and female wages and controlling for education, it looks at the earnings of men and women with the same level and quality of education.
This research provides new information about the gender pay gap across a range of postsecondary education levels from graduates of the most selective bachelor programs to graduates of certificate programs.
The Census Bureau analyzed the earnings of graduates from certificate, associate and bachelor’s programs for up to 15 years. It estimated the magnitude of the earnings gap at these educational levels and three factors that may contribute to it: field of study; occupation and industry after graduation; and number of weeks and hours worked in a year.
This research was made possible by a partnership between the Census Bureau and state higher education systems, which provided student transcript records that can be linked to other datasets.
In this case, the student records were linked to the American Community Survey (ACS) to gauge post-graduation outcomes such as earnings, occupation, childbearing, and the number of weeks and hours worked. The ACS is the premier source of detailed population and housing information about our nation.
Researchers analyzed the gender pay gap using a statistical model that answered the following questions for each degree level considered:
• How large was the gap between men’s and women’s earnings, on average? • How much of this gap was driven by women and men majoring in different fields? • Among women and men with the same education level who graduated in the same field, how much of the gap stemmed from women and men working in different occupations and industries? • Among men and women with the same education level, who graduated in the same field and worked in the same occupation, how much of the gap was caused by women and men participating in the workforce at different rates and working different numbers of weeks and hours-per-week during the year? • How much of the gender pay gap was due to other factors?
Answers differed considerably depending on whether someone graduated from a certificate or selective bachelor’s program.
The size of the gender earnings gap
The gap in average earnings from 2005 to 2019 was consistent across all education levels. As shown in Figure 1, women with a certificate degree earned 71.2 cents for every dollar earned by men with a certificate degree. In other words, the gap was 28.8%. For graduates of the most selective bachelor’s institutions, as defined by the Barron’s Admissions Competitiveness Index, the gap was 28.4%.
This gap is larger than the 84 cents for every dollar earned figure reported by the White House, which compares full-time, year-round working men and women. The comparisons in this report are between graduates.
Field of study
College major or field of study accounted for a substantial portion of the gap at higher education levels but were less significant at lower levels.
For example, 3.8% of the gender gap in earnings among those with certificate degrees was attributed to choice of major/field of study, compared to 24.6% among graduates of the most selective bachelor’s programs (Figure 2).
After accounting for differences in choice of major, the share of the gap due to occupation and industry chosen was nearly the same regardless of education level.
Occupational choices accounted for 38.5% of the gap among certificate degree graduates and 32.4% of the gap among graduates of selective bachelor’s programs (Figure 2).
Differences in labor supply — which reflect a combination of gender differences in employment rates as well as gender differences in the number of weeks and hours-per-week worked in a year of those employed — had a greater impact on the pay gap among graduates of certificate and associate programs than among those with bachelor’s degrees.
Labor supply accounted for 26.4% of the pay gap among certificate holders but only 11.3% among graduates of the most selective bachelor’s programs (Figure 2).
In Figures 2 and 4, the “unexplained” is the share of the gap that is not explained by differences in field of study, occupation and industry, or hours and weeks worked.
The children factor
Previous research has shown that having children contributed significantly to the gender pay gap.
And as Figure 3 shows, this study found the wage gap was considerably wider among men and women with than without children — more than double for top bachelor’s holders and quadruple for certificate graduates.
Figure 4 illustrates this jump was mostly fueled by labor supply among graduates of certificate programs and by occupation and labor supply choices among grads of highly selective bachelor’s programs.
Gender pay gap varied across the educational attainment distribution
Until recently, data limitations prevented researchers from investigating variations in the gender pay gap across different types of degrees and paths taken by graduates.
Thanks to our partnership with higher education systems, we can now get to the bottom of whether and how the gender pay gap relates to types of degrees earned.
The results paint a more complex portrait of the gender pay gap, found to exist at every level. College graduates and policymakers can use this more detailed information to better understand and dismantle contemporary barriers to gender equality.
Ariel Binder, Amanda Eng and Kendall Houghton are economists in the Center for Economic Studies Demographic Research Area. Andrew Foote is a principal economist in the Center for Economic Studies LEHD Research Area. All are U.S. Census Bureau staffers.
LAKE COUNTY, Calif. — Lake County Animal Care and Control has dozens of pets waiting to be adopted.
Dogs available for adoption this week include mixes of Anatolian shepherd, Australian shepherd, border collie, boxer, German shepherd, Great Pyrenees, hound, husky, Labrador retriever, pit bull, Queensland heeler, shepherd and terrier.
Dogs that are adopted from Lake County Animal Care and Control are either neutered or spayed, microchipped and, if old enough, given a rabies shot and county license before being released to their new owner. License fees do not apply to residents of the cities of Lakeport or Clearlake.
Those dogs and the others shown on this page at the Lake County Animal Care and Control shelter have been cleared for adoption.
Call Lake County Animal Care and Control at 707-263-0278 or visit the shelter online for information on visiting or adopting.
The shelter is located at 4949 Helbush in Lakeport.
Email Elizabeth Larson at This email address is being protected from spambots. You need JavaScript enabled to view it.. Follow her on Twitter, @ERLarson, or Lake County News, @LakeCoNews.
CLEARLAKE, Calif. — Clearlake Animal Control has many more new dogs awaiting their families this week.
The Clearlake Animal Control website lists 52 adoptable dogs.
This week’s dogs include “Annie,” a female Siberian husky mix with a white coat and blue eyes.
There also is “Rose,” a female pit bull terrier mix with a copper and white coat.
The shelter is located at 6820 Old Highway 53. It’s open from 9 a.m. to 6 p.m. Tuesday through Saturday.
For more information, call the shelter at 707-762-6227, email This email address is being protected from spambots. You need JavaScript enabled to view it., visit Clearlake Animal Control on Facebook or on the city’s website.
This week’s adoptable dogs are featured below.
Email Elizabeth Larson at This email address is being protected from spambots. You need JavaScript enabled to view it.. Follow her on Twitter, @ERLarson, or Lake County News, @LakeCoNews.
The U.S. Congress designated March as Irish American Heritage Month in 1991 and the president issues a proclamation commemorating the occasion each year.
Originally a religious holiday to honor St. Patrick who introduced Christianity to Ireland in the fifth century, St. Patrick’s Day has evolved into a celebration of all things Irish.
The world’s first St. Patrick’s Day parade occurred on March 17, 1762, in New York City, featuring Irish soldiers who served in the English military. This parade became an annual event, with President Truman attending in 1948.
The following facts are made possible by the invaluable responses to U.S. Census Bureau surveys.
Did You Know?
30.7 million or 9.2% The number and percentage of U.S. residents who claimed Irish ancestry in 2022.
112,251 The number of foreign-born U.S. residents who reported Ireland as their birthplace in 2022.
418,997 The number of people living in Cook County, Illinois — the nation’s county with the largest Irish American population — who claimed Irish ancestry in 2022.
11.1% The percentage of residents in Lake County, California, who claim Irish heritage. That makes Irish the third-largest ancestry claimed by county residents, following German (15.5%) and English (11.9%).
Is or was there life on Mars? That profound question is so complex that it will not be fully answered by the two NASA rovers now exploring it.
But because of the literal groundwork the rovers are performing, scientists are finally investigating, in-depth and in unprecedented detail, the planet’s evidence for life, known as its “biosignatures.” This search is remarkably complicated, and in the case of Mars, it is spanning decades.
As a geologist, I have had the extraordinary opportunity to work on both the Curiosity and Perseverance rover missions. Yet as much as scientists are learning from them, it will take another robotic mission to figure out if Mars has ever hosted life. That mission will bring Martian rocks back to Earth for analysis. Then – hopefully – we will have an answer.
From habitable to uninhabitable
While so much remains mysterious about Mars, there is one thing I am confident about. Amid the thousands of pictures both rovers are taking, I’m quite sure no alien bears or meerkats will show up in any of them. Most scientists doubt the surface of Mars, or its near-surface, could currently sustain even single-celled organisms, much less complex forms of life.
Instead, the rovers are acting as extraterrestrial detectives, hunting for clues that life may have existed eons ago. That includes evidence of long-gone liquid surface water, life-sustaining minerals and organic molecules. To find this evidence, Curiosity and Perseverance are treading very different paths on Mars, more than 2,000 miles (3,200 kilometers) from each other.
These two rovers will help scientists answer some big questions: Did life ever exist on Mars? Could it exist today, perhaps deep under the surface? And would it be only microbial life, or is there any possibility it might be more complex?
The Mars of today is nothing like the Mars of several billion years ago. In its infancy, Mars was far more Earth-like, with a thicker atmosphere, rivers, lakes, maybe even oceans of water, and the essential elements needed for life. But this period was cut short when Mars lost its magnetic field and nearly all of its atmosphere – now only 1% as dense as the Earth’s.
The change from habitable to uninhabitable took time, perhaps hundreds of millions of years; if life ever existed on Mars, it likely died out a few billion years ago. Gradually, Mars became the cold and dry desert that it is today, with a landscape comparable to the dry valleys of Antarctica, without glaciers and plant or animal life. The average Martian temperature is minus 80 degrees Fahrenheit (minus 62 degrees Celsius), and its meager atmosphere is nearly all carbon dioxide.
Early exploration
Robotic exploration of the Martian surface began in the 1970s, when life-detection experiments on the Viking missions failed to find any conclusive evidence for life.
Sojourner, the first rover, landed in 1997 and demonstrated that a moving robot could perform experiments. In 2004, Spirit and Opportunity followed; both found evidence that liquid water once existed on the Martian surface.
The Curiosity rover landed in 2012 and began ascending Mount Sharp, the 18,000-foot-high mountain located inside Gale crater. There is a reason why NASA chose it as an exploration site: The mountain’s rock layers show a dramatic shift in climate, from one with abundant liquid water to the dry environment of today.
So far, Curiosity has found evidence in several locations of past liquid water, minerals that may provide chemical energy, and intriguingly, a variety of organic carbon molecules.
While organic carbon is not itself alive, it is a building block for all life as we know it. Does its presence mean that life once existed on Mars?
Not necessarily. Organic carbon can be abiotic – that is, unrelated to a living organism. For example, maybe the organic carbon came from a meteorite that crashed on Mars. And though the rovers carry wonderfully sophisticated instruments, they can’t definitively tell us if these organic molecules are related to past life on Mars.
But laboratories here on Earth likely can. By collecting rock and soil samples from the Martian surface, and then returning them to Earth for detailed analysis with our state-of-the-art instruments, scientists may finally have the answer to an age-old question.
Perseverance
Enter Perseverance, NASA’s newest flagship mission to Mars. For the past three years – it landed in February 2021 – Perseverance has been searching for signs of bygone microbial life in the rocks within Jezero crater, selected as the landing site because it once contained a large lake.
Perseverance is the first step of the Mars Sample Return mission, an international effort to collect Martian rock and soil for return to Earth.
The instrument suite onboard Perseverance will help the science team choose the rocks that seem to promise the most scientific return. This will be a careful process; after all, there would be only 30 seats on the ride back to Earth for these geological samples.
Budget woes
NASA’s original plan called for returning those samples to Earth by 2033. But work on the mission – now estimated to cost between US$8 billion to $11 billion – has slowed due to budget cuts and layoffs. The cuts are severe; a request for $949 million to fund the mission for fiscal 2024 was trimmed to $300 million, although efforts are underway to restore at least some of the funding.
The Mars Sample Return mission is critical to better understand the potential for life beyond Earth. The science and the technology that will enable it are both novel and expensive. But if NASA discovers life once existed on Mars – even if it’s by finding a microbe dead for a billion years – that will tell scientists that life is not a fluke one-time event that only happened on Earth, but a more common phenomenon that could occur on many planets.
That knowledge would revolutionize the way human beings see ourselves and our place in the universe. There is far more to this endeavor than just returning some rocks.
UC San Francisco researchers have designed a candidate drug that could help make pancreatic cancer, which is almost always fatal, a treatable, perhaps even curable, condition.
The new drug candidate permanently modifies a wily cancer-causing mutation, called K-Ras G12D, that is responsible for nearly half of all pancreatic cancer cases and appears in some forms of lung, breast and colon cancer.
Pancreatic cancer is less common than these other cancers, but the lack of treatment options makes it more deadly, and it claims more than 50,000 lives each year in the United States.
“We’ve worked for 10 years to bring pancreatic cancer therapies up to speed with therapies for other cancers,” said Kevan Shokat, PhD, a professor in the Department of Cellular and Molecular Pharmacology who led the work. “This breakthrough is the first to target G12D and gives us a firm foothold to fight this devastating mutation.”
The findings appear March 5, 2024, in Nature Chemical Biology.
Shokat and his colleagues developed the first cancer drugs to stop a different K-Ras mutation, G12C, in 2013. Since then, two therapies have been approved for use in lung and breast cancer, but the advance didn’t move the needle for treating pancreatic cancer.
An extremely common mutation
K-Ras mutations are extremely common in pancreatic cancer, explaining 90% of cases. About half of these mutations are G12D, which differs from most other K-Ras mutations by a single amino acid substitution.
This difference between healthy and cancer-causing proteins, in which glycine (G) becomes aspartate (D), presented a monumental challenge for chemists.
“There are very few molecules out there that can sense the difference between the cancer-causing aspartate and the glycine,” Shokat said. “To make good therapies, we need drugs that work on the tumor cells only, without affecting healthy cells.”
Shokat’s team envisioned a molecule that fit into a pocket of the K-Ras protein, then firmly – and irreversibly – bound to the rogue aspartate. The explosion of research that followed Shokat’s 2013 discovery enabled them to develop a template for chemicals that reliably found their way into that corner of the protein.
“Once we had that structure for our molecules, we knew they were sitting in the protein at the right spot,” Shokat said. “Then we could explore the little nooks and crannies that we needed to discover the chemistry of the aspartate.”
Could a bend in a molecule lead to a cure?
The scientists went through dozens of chemicals.
“It’s like climbing a new route on a mountain, you may be strong but the lengths of your arms limit what you can do,” Shokat said. “It was a lot of trial and error, tweaking the branches of these molecules to position them in this incredibly tight space around G12D. Some got close, then failed, and we would start over.”
Eventually, they found a winning molecule. It settled into the appropriate corner of K-Ras and bent into a new shape that reacted strongly with the aspartate.
The molecule put the brakes on tumor growth from G12D in cancer cell lines, as well as an animal model of human cancer. And it never attacked healthy proteins.
The scientists are now optimizing the molecule to be durable enough to fight cancer in the human body. With the traction gained from this study, Shokat said, new therapies for pancreatic cancer could enter clinical trials in as little as two to three years.
“We’ve learned a lot from other targeted therapies and know how to quickly translate discoveries like these for the clinic,” said Margaret Tempero, MD, director of the UCSF Pancreas Center. “An effective drug targeting K-RAS G12D could be transformative for patients with pancreatic cancer.”
For funding and disclosures, see the paper. Other UCSF authors are Quinheng Zheng, Ziyang Zhang, and Keelan Z. Guiley. Zhang is now a professor at UC Berkeley.
Levi Gadye writes for the University of California, San Francisco.